After nearly 10 years running his own venture capital firm, Nick Chirls decided to call it quits this year.

His firm, Notation Capital, had raised three funds and invested in more than 100 companies. But Mr. Chirls said he had become disillusioned as venture capital grew from a collection of small partnerships into an industry dominated by firms that managed enormous sums.

The focus on accumulating and deploying as much money as possible “completely dehumanized the entire business,” he said.

Instead, Mr. Chirls is starting a new kind of firm. From the outside, the endeavor, Asylum Ventures, looks like his old firm, with a $55 million venture fund that will invest in very young tech companies. But the approach is set to be very different, making fewer investments over a longer period in companies that will not need to raise increasingly large funding rounds, he said.

Mr. Chirls and his partners, Jonathan Wu and Mackenzie Regent, are part of a small but vocal group of start-up investors who are pushing back against venture capital’s changing scope and priorities. Venture capital investing has traditionally involved small groups of financiers who backed very young, very risky companies that couldn’t obtain traditional loans. The sums invested were often small.

But that changed in recent years as investors poured billions of dollars into unproven start-ups with little diligence and investment firms expanded rapidly into new strategies and geographies. Last year, venture capital managed $1.1 trillion, up from $297 billion in 2013, according to PitchBook, which tracks start-ups.

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